BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuAnti-glomerular basement membrane diseaseGoodpasture syndrome; Rapidly progressive glomerulonephritis with pulmonary hemorrhage; Pulmonary renal syndrome; Glomerulonephritis - pulmonary hemorrhage Anti-glomerular basement membrane diseases (anti-GBM diseases) is a rare disorder that can involve quickly worsening kidney failure and lung disease.Quickly worsening kidney failureGlomerulonephritis is a type of kidney disease in which the part of your kidneys that helps filter waste and fluids from the blood is damaged....ImageRead Article Now Book Mark Article Some forms of the disease involve just the lung or the kidney. Anti-GBM disease used to be known as Goodpasture syndrome. Causes Anti-GBM disease is an autoimmune disorder. It occurs when the immune system mistakenly attacks and destroys healthy body tissue. People with this syndrome develop substances that attack a protein called collagen in the tiny air sacs in the lungs and the filtering units (glomeruli) of the kidneys.Autoimmune disorderAn autoimmune disorder occurs when the body's immune system attacks and destroys healthy body tissue by mistake. There are more than 80 types of aut...ImageRead Article Now Book Mark Article These substances are called antiglomerular basement membrane antibodies. The glomerular basement membrane is a part of the kidneys that helps filter waste and extra fluid from the blood. Antiglomerular basement membrane antibodies are antibodies against this membrane. They can damage the basement membrane, which can lead to kidney damage.AntibodiesAn antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include micr...ImageRead Article Now Book Mark Article Sometimes, this disorder is triggered by a viral respiratory infection or by breathing in hydrocarbon solvents. In such cases, the immune system may attack organs or tissues because it mistakes them for these viruses or foreign chemicals.The immune system's faulty response causes bleeding in the air sacs of the lungs and inflammation in the kidney's filtering units. Symptoms Symptoms may occur very slowly over months or even years, but they often develop very quickly over days to weeks.Loss of appetite, fatigue, and weakness are common early symptoms.WeaknessWeakness is reduced strength in one or more muscles.Read Article Now Book Mark Article Lung symptoms may include:Coughing up blood Dry cough CoughCoughing is an important way to keep your throat and airways clear. But too much coughing may mean you have a disease or disorder. Some coughs are d...ImageRead Article Now Book Mark Article Shortness of breathKidney and other symptoms include:Bloody urine Bloody urineBlood in your urine is called hematuria. The amount may be very small and only detected with urine tests or under a microscope. In other cases, the...ImageRead Article Now Book Mark Article Burning sensation when urinating Nausea and vomiting Nausea and vomitingNausea is feeling an urge to vomit. It is often called "being sick to your stomach. "Vomiting or throwing-up is forcing the contents of the stomach ...ImageRead Article Now Book Mark Article Pale skin Pale skinPaleness is an abnormal loss of color from normal skin or mucous membranes.Read Article Now Book Mark Article Swelling (edema) in any area of the body, especially in the legs Exams and Tests A physical exam may reveal signs of high blood pressure and fluid overload. The health care provider may hear abnormal heart and lung sounds when listening to the chest with a stethoscope.High blood pressureBlood pressure is a measurement of the force exerted against the walls of your arteries as your heart pumps blood to your body. Hypertension is the ...ImageRead Article Now Book Mark Article Urinalysis results are often abnormal and show blood and protein in the urine. Abnormal red blood cells may be seen.The following tests may also be done:Antiglomerular basement membrane test Antiglomerular basement membrane testThe glomerular basement membrane is the part of the kidney that helps filter waste and extra fluid from the blood. Anti-glomerular basement membrane ...ImageRead Article Now Book Mark Article Arterial blood gas Arterial blood gasBlood gases are a measurement of how much oxygen and carbon dioxide are in your blood. They also determine the acidity (pH) of your blood.ImageRead Article Now Book Mark Article BUN BUN BUN stands for blood urea nitrogen. Urea nitrogen is what forms when protein breaks down. A test can be done to measure the amount of urea nitrogen ...Read Article Now Book Mark Article Chest x-ray Chest x-rayA chest x-ray is an x-ray of the chest, lungs, heart, large arteries, ribs, and diaphragm.ImageRead Article Now Book Mark Article Creatinine (serum) CreatinineThe creatinine blood test measures the level of creatinine in the blood. This test is done to see how well your kidneys are working. Creatinine can ...ImageRead Article Now Book Mark Article Lung biopsy Lung biopsyA lung needle biopsy is a method to remove a piece of lung tissue for examination. If it is done through the wall of your chest, it is called a tran...ImageRead Article Now Book Mark Article Kidney biopsyKidney biopsyA kidney biopsy is the removal of a small piece of kidney tissue for examination.ImageRead Article Now Book Mark Article Treatment The main goal is to remove the harmful antibodies from the blood. Treatment may include:Plasmapheresis, which removes harmful antibodies to help reduce inflammation in the kidneys and lungs. Corticosteroid medicines (such as prednisone) and other drugs, which suppress or quiet the immune system. Medicines such as angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), which help control blood pressure. Dialysis, which may be done if kidney failure can no longer be treated. DialysisDialysis treats end-stage kidney failure. It removes harmful substances from the blood when the kidneys cannot. This article focuses on peritoneal d...Read Article Now Book Mark Article A kidney transplant, which may be done when your kidneys no longer function.Kidney transplantA kidney transplant is surgery to place a healthy kidney into a person with kidney failure.ImageRead Article Now Book Mark Article You may be told to limit your intake of salt and fluids to control swelling. In some cases, a low-to-moderate protein diet may be recommended. Support Groups More information and support for people with anti-GBM disease and their families can be found at:National Institute of Diabetes and Digestive and Kidney Diseases -- www.niddk.nih.gov/health-information/kidney-disease/glomerular-diseases/anti-gbm-goodpastures-disease National Kidney Foundation -- www.kidney.org/atoz/content/goodpasture National Organization for Rare Disorders -- rarediseases.org/rare-diseases/goodpasture-syndrome Outlook (Prognosis) An early diagnosis is very important. The outlook is much worse if the kidneys are already severely damaged when treatment begins. Lung damage can range from mild to severe.Many people will need dialysis or a kidney transplant. Possible Complications Untreated, this condition can lead to any of the following:Chronic kidney disease Chronic kidney diseaseChronic kidney disease is the slow loss of kidney function over time. The main job of the kidneys is to remove wastes and excess water from the body...ImageRead Article Now Book Mark Article End-stage kidney disease End-stage kidney diseaseEnd-stage kidney disease (ESKD) is the last stage of long-term (chronic) kidney disease. This is when your kidneys can no longer support your body's...ImageRead Article Now Book Mark Article Lung failure Rapidly progressive glomerulonephritis Rapidly progressive glomerulonephritisGlomerulonephritis is a type of kidney disease in which the part of your kidneys that helps filter waste and fluids from the blood is damaged....ImageRead Article Now Book Mark Article Severe pulmonary hemorrhage (lung bleeding) When to Contact a Medical Professional Call for an appointment with your provider if you are producing less urine, or you have any other symptoms of anti-GBM disease. Prevention Never sniff glue or siphon gasoline with your mouth, which exposes the lungs to hydrocarbon solvents and can cause the disease.Open ReferencesReferencesSchwarz MI, Matson S. Diffuse alveolar hemorrhage. In: Broaddus VC, Ernst JD, King TE, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine.7th ed. Philadelphia, PA: Elsevier; 2022:chap 94.Phelps RG, Turner AN. Anti-glomerular basement membrane disease and Goodpasture disease. In: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Comprehensive Clinical Nephrology. 6th ed. Philadelphia, PA: Elsevier; 2019:chap 24.Radhakrishnan J, Appel GB, D'Agati VD. Secondary glomerular disease. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 32.AllVideoImagesTogKidney blood supply - illustration The renal arteries supply the kidneys with blood.Kidney blood supplyillustrationGlomerulus and nephron - illustration The kidneys remove excess fluid and waste from your body. Blood is filtered in the kidneys through nephrons. Each nephron contains a network of small blood vessels, called glomerulus, which are enclosed in a sac called Bowman's capsule. The filtered waste product (urine) flows through tiny tubes and is then passed from the kidneys to the bladder through bigger tubes called ureters.Glomerulus and nephronillustrationKidney blood supply - illustration The renal arteries supply the kidneys with blood.Kidney blood supplyillustrationGlomerulus and nephron - illustration The kidneys remove excess fluid and waste from your body. Blood is filtered in the kidneys through nephrons. Each nephron contains a network of small blood vessels, called glomerulus, which are enclosed in a sac called Bowman's capsule. The filtered waste product (urine) flows through tiny tubes and is then passed from the kidneys to the bladder through bigger tubes called ureters.Glomerulus and nephronillustration Tests for Anti-glomerular basement membrane disease Anti-glomerular basement membrane blood testRelated Information Respiratory(Special Topic)Chronic kidney disease(Condition)End-stage kidney disease(Condition) Review Date: 7/27/2021 Reviewed By: Walead Latif, MD, Nephrologist and Clinical Associate Professor, Rutgers Medical School, Newark, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- © 1997- All rights reserved. A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.Content is best viewed in IE9 or above, Firefox and Google Chrome browser.