BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuEosinophilic fasciitisShulman syndromeEosinophilic fasciitis (EF) is a syndrome in which tissue under the skin and over the muscle, called fascia, becomes swollen, inflamed and thick. The skin on the arms, legs, neck, abdomen or feet can swell quickly. The condition is very rare.EF may look similar to scleroderma, but is not related. Unlike scleroderma, in EF, the fingers are not involved. SclerodermaScleroderma is a disease that involves the buildup of scar-like tissue in the skin and elsewhere in the body. It also damages the cells that line th...ImageRead Article Now Book Mark Article Causes The cause of EF is unknown. Rare cases have occurred after taking L-tryptophan supplements. In people with this condition, white blood cells, called eosinophils, build up in the muscles and tissues. Eosinophils are linked to allergic reactions. The syndrome is more common in people ages 30 to 60. Symptoms Symptoms may include:Tenderness and swelling of the skin on the arms, legs, or sometimes the joints (most often on both sides of the body) Arthritis ArthritisArthritis is inflammation or degeneration of one or more joints. A joint is the area where 2 bones meet. There are more than 100 different types of...ImageRead Article Now Book Mark Article Carpal tunnel syndrome Carpal tunnel syndromeCarpal tunnel syndrome is a condition in which there is excessive pressure on the median nerve. This is the nerve in the wrist that allows feeling a...ImageRead Article Now Book Mark Article Muscle pain Thickened skin that looks puckered Exams and Tests Tests that may be done include:CBC with differential Gamma globulins (a type of immune system protein) Erythrocyte sedimentation rate (ESR) ESRESR stands for erythrocyte sedimentation rate. It is commonly called a "sed rate. "It is a test that indirectly measures the level of certain protei...Read Article Now Book Mark Article MRI MRIA magnetic resonance imaging (MRI) scan is an imaging test that uses powerful magnets and radio waves to create pictures of the body. It does not us...ImageRead Article Now Book Mark Article Muscle biopsy Muscle biopsyA muscle biopsy is the removal of a small piece of muscle tissue for examination.ImageRead Article Now Book Mark Article Skin biopsy (the biopsy needs to include the deep tissue of the fascia)Skin biopsyA skin lesion biopsy is when a small amount of skin is removed so it can be examined. The skin is tested to look for skin conditions or diseases. A...ImageRead Article Now Book Mark Article Treatment Corticosteroids and other immune-suppressing medicines are used to relieve symptoms. These medicines are more effective when started early in the disease. Nonsteroidal anti-inflammatory drugs (NSAIDs) may also help reduce symptoms. Outlook (Prognosis) In most cases, the condition goes away within 1 to 3 years. However, symptoms may last longer or come back. Possible Complications Arthritis is a rare complication of EF. Some people may develop very serious blood disorders or blood-related cancers, such as aplastic anemia or leukemia. The outlook is much worse if blood diseases occur.LeukemiaLeukemia is a type of blood cancer that begins in the bone marrow. Bone marrow is the soft tissue in the center of the bones, where blood cells are ...ImageRead Article Now Book Mark Article When to Contact a Medical Professional Call your health care provider if you have symptoms of this disorder. Prevention There is no known prevention.Open ReferencesReferencesAronson JK. Tryptophan. In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier B.V.; 2016:220-221.Florentino DF, Werth VP. Skin and rheumatic diseases. In: Firestein GS, Budd RC, Gabriel SE, Koretzky GA, McInnes IB, O'Dell JR, eds. Firestein & Kelley's Textbook of Rheumatology. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 46.James WD, Elston DM, Treat JR, Rosenbach MA, Neuhaus IM. Connective tissue diseases. In: James WD, Elston DM, Treat JR, Rosenbach MA, Neuhaus IM, eds. Andrews' Diseases of the Skin: Clinical Dermatology. 13th ed. Philadelphia, PA: Elsevier; 2020:chap 8.National Organization for Rare Disorders. Eosinophilic fasciitis. rarediseases.org/rare-diseases/eosinophilic-fasciitis/. Updated 2016. Accessed May 10, 2021.Pinal-Fernandez I, Selva-O' Callaghan A, Grau JM. Diagnosis and classification of eosinophilic fasciitis. Autoimmun Rev. 2014;13(4-5):379-382. PMID: 24424187 pubmed.ncbi.nlm.nih.gov/24424187/.AllVideoImagesTogSuperficial anterior muscles - illustration Superficial muscles are close to the surface of the skin. Muscles which lie closer to bone or internal organs are called deep muscles.Superficial anterior musclesillustrationSuperficial anterior muscles - illustration Superficial muscles are close to the surface of the skin. Muscles which lie closer to bone or internal organs are called deep muscles.Superficial anterior musclesillustrationRelated Information Eosinophil count - absolute(Medical Test) Review Date: 1/31/2021 Reviewed By: Diane M. Horowitz, MD, Rheumatology and Internal Medicine, Northwell Health, Great Neck, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. 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