BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuParinaud oculoglandular syndromeCat scratch disease; Oculoglandular syndromeParinaud oculoglandular syndrome is an eye problem that is similar to conjunctivitis ("pink eye"). It most often affects only one eye. It occurs with swollen lymph nodes and an illness with a fever.Swollen lymph nodesLymph nodes are present throughout your body. They are an important part of your immune system. Lymph nodes help your body recognize and fight germ...ImageRead Article Now Book Mark Article Note: Parinaud syndrome (also called upgaze paresis) is a different disorder in which you have trouble looking upward. This can be caused by a brain tumor, and requires an immediate evaluation by your health care provider. Causes Parinaud oculoglandular syndrome (POS) is caused by an infection with bacteria, a virus, fungus, or parasite.The most common causes are cat scratch disease and tularemia (rabbit fever). The bacteria that cause either condition can infect the eye. The bacteria can directly enter the eye (on a finger or other object), or air droplets that carry the bacteria can land on the eye.TularemiaTularemia is a bacterial infection in wild rodents. The bacteria are passed to humans through contact with tissue from the infected animal. The bac...ImageRead Article Now Book Mark Article Other infectious diseases may spread the same way, or through the bloodstream to the eye. Symptoms Symptoms include:Red, irritated, and painful eye (looks like "pink eye") Fever General ill feeling Increased tearing (possible) Swelling of nearby lymph glands (often in front of the ear) Exams and Tests An exam shows:Fever and other signs of illness Red, tender, inflamed eye Tender lymph nodes may be present in front of the ear There may be growths (conjunctival nodules) on the inside of the eyelid or the white of the eye Blood tests will be done to check for infection. The white blood cell count may be high or low, depending on the cause of the infection.White blood cellA WBC count is a blood test to measure the number of white blood cells (WBCs) in the blood. WBCs are also called leukocytes. They help fight infecti...ImageRead Article Now Book Mark Article A blood test to check antibody levels is the main method used to diagnose many of the infections that cause POS. Other tests may include:Biopsy of the lymph node Biopsy of the lymph nodeA lymph node biopsy is the removal of lymph node tissue for examination under a microscope. The lymph nodes are small glands that make white blood ce...ImageRead Article Now Book Mark Article Laboratory culture of eye fluids, lymph node tissue, or blood Treatment Depending on the cause of the infection, antibiotics may be helpful. Surgery may be needed in rare cases to clean away the infected tissues. Outlook (Prognosis) The outlook depends on the cause of the infection. In general, if the diagnosis is made early and treatment starts right away, the outcome of POS can be very good. Possible Complications Serious complications are rare.The conjunctival nodules can sometimes form sores (ulcers) during the healing process. The infection can spread to nearby tissues or into the bloodstream. When to Contact a Medical Professional You should call your provider if you develop a red, irritated, painful eye. Prevention Frequent hand washing can reduce the likelihood of getting POS. Avoid being scratched by a cat, even a healthy cat. You can avoid tularemia by not having contact with wild rabbits, squirrels, or ticks.Open ReferencesReferencesGruzensky WD. Parinaud oculoglandular syndrome. In: Mannis MJ, Holland EJ, eds. Cornea. 4th ed. Philadelphia, PA: Elsevier; 2017:chap 45.Pecora N, Milner DA. New technologies for the diagnosis of infection, In: Kradin RL, ed. Diagnostic Pathology of Infectious Disease. 2nd ed. Philadelphia, PA: Elsevier; 2018:chap 6.Rubenstein JB, Spektor T. Conjunctivitis: infectious and noninfectious. In: Yanoff M, Duker JS, eds. Ophthalmology. 5th ed. Philadelphia, PA: Elsevier; 2019:chap 4.6.Salmon JF. Conjunctiva. In: Salmon JF, ed. Kanski's Clinical Ophthalmology. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 6.AllVideoImagesTogSwollen lymph node - illustration Lymph nodes play an important part in the body's defense against infection. Swelling might occur even if the infection is trivial or not apparent. Swelling of lymph nodes generally results from localized or systemic infection, abscess formation, or malignancy.Swollen lymph nodeillustrationSwollen lymph node - illustration Lymph nodes play an important part in the body's defense against infection. Swelling might occur even if the infection is trivial or not apparent. Swelling of lymph nodes generally results from localized or systemic infection, abscess formation, or malignancy.Swollen lymph nodeillustrationRelated Information Swollen lymph nodes(Symptoms)Tularemia(Condition)Lyme disease and related tick-borne infections(In-Depth) Review Date: 8/18/2020 Reviewed By: Franklin W. Lusby, MD, ophthalmologist, Lusby Vision Institute, La Jolla, CA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. 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