BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuPlummer-Vinson syndromePaterson-Kelly syndrome; Sideropenic dysphagia; Esophageal webPlummer-Vinson syndrome is a condition that can occur in people with long-term (chronic) iron deficiency anemia. People with this condition have problems swallowing due to small, thin growths of tissue that partially block the upper food pipe (esophagus).Iron deficiency anemiaAnemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body tissues. There are man...ImageRead Article Now Book Mark Article Causes The cause of Plummer-Vinson syndrome is unknown. Genetic factors and a lack of certain nutrients (nutritional deficiencies) may play a role. It is a rare disorder that can be linked to cancers of the esophagus and throat. It is more common in women. Symptoms Symptoms may include:Difficulty swallowing Weakness Exams and Tests Your health care provider will do an exam to look for abnormal areas on your skin and nails.You may have an upper GI series or upper endoscopy to look for abnormal tissue in the food pipe. You may have tests to look for anemia or iron deficiency. Upper GI seriesAn upper GI and small bowel series is a set of x-rays taken to examine the esophagus, stomach, and small intestine. Barium enema is a related test th...ImageRead Article Now Book Mark Article Upper endoscopyEsophagogastroduodenoscopy (EGD) is a test to examine the lining of the esophagus, stomach, and first part of the small intestine (the duodenum)....ImageRead Article Now Book Mark Article Treatment Taking iron supplements may improve the swallowing problems.If supplements do not help, the web of tissue can be widened during upper endoscopy. This will allow you to swallow food normally. Outlook (Prognosis) People with this condition generally respond to treatment. Possible Complications Devices used to stretch the esophagus (dilators) may cause a tear. This can lead to bleeding.Plummer-Vinson syndrome has been linked to esophageal cancer.Esophageal cancerEsophageal cancer is cancer that starts in the esophagus. This is the tube through which food moves from the mouth to the stomach.ImageRead Article Now Book Mark Article When to Contact a Medical Professional Call your provider if:Food gets stuck after you swallow it You have severe fatigue and weakness Prevention Getting enough iron in your diet may prevent this disorder.Open ReferencesReferencesHammad H, Wani S. Esophageal tumors. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th ed. Philadelphia, PA: Elsevier; 2021:chap 48.Kavitt RT, Vaezi MF. Diseases of the esophagus. In: Flint PW, Francis HW, Haughey BH, et al, eds. Cummings Otolaryngology: Head and Neck Surgery. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 68.Rustgi AK. Neoplasms of the esophagus and stomach. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 183.AllVideoImagesTogEsophagus and stomach anatomy - illustration Food is swallowed and passes through the esophagus to the stomach, where the majority of digestion takes place.Esophagus and stomach anatomyillustrationEsophagus and stomach anatomy - illustration Food is swallowed and passes through the esophagus to the stomach, where the majority of digestion takes place.Esophagus and stomach anatomyillustrationRelated Information Iron deficiency anemia(Condition)Esophageal cancer(Condition)Anemia(In-Depth) Review Date: 10/28/2020 Reviewed By: Michael M. Phillips, MD, Clinical Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- © 1997- All rights reserved. A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.Content is best viewed in IE9 or above, Firefox and Google Chrome browser.