BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuGianotti-Crosti syndromePapular acrodermatitis of childhood; Infantile acrodermatitis; Acrodermatitis - infantile lichenoid; Acrodermatitis - papular infantile; Papulovesicular acro-located syndromeGianotti-Crosti syndrome is a childhood skin condition that may be accompanied by mild symptoms of fever and malaise. It may also be associated with hepatitis B and other viral infections.MalaiseMalaise is a general feeling of discomfort, illness, or lack of well-being.Read Article Now Book Mark Article Causes Health care providers don't know the exact cause of this disorder. They do know that it is linked with other infections.In Italian children, Gianotti-Crosti syndrome is seen frequently with hepatitis B. But this link is rarely seen in the United States. Epstein-Barr virus (EBV, mononucleosis) is the virus most often associated with acrodermatitis.Hepatitis BHepatitis B is irritation and swelling (inflammation) of the liver due to infection with the hepatitis B virus (HBV). Other types of viral hepatitis ...ImageRead Article Now Book Mark Article MononucleosisMononucleosis, or mono, is a viral infection that causes fever, sore throat, and swollen lymph glands, most often in the neck.ImageRead Article Now Book Mark Article Other associated viruses include:Cytomegalovirus CytomegalovirusCytomegalovirus (CMV) infection is a disease caused by a type of herpes virus.ImageRead Article Now Book Mark Article Coxsackie viruses Parainfluenza virus Respiratory syncytial virus (RSV) RSVRespiratory syncytial virus (RSV) is a very common virus that leads to mild, cold-like symptoms in adults and older healthy children. It can be more...ImageRead Article Now Book Mark Article Some types of live virus vaccines Symptoms Skin symptoms may include any of the following:Rash or patch on the skin, usually on the arms and legs Brownish-red or copper-colored patch that is firm and flat on top String of bumps may appear in a line Generally not itchy Rash looks the same on both sides of the body Rash may appear on the palms and soles, but not on the back, chest, or belly area (this is one of the ways it is identified, by the absence of the rash from the trunk of the body) Other symptoms that may appear include:Swollen abdomen Swollen abdomenA swollen abdomen is when your belly area is bigger than usual.Read Article Now Book Mark Article Swollen lymph nodes Swollen lymph nodesLymph nodes are present throughout your body. They are an important part of your immune system. Lymph nodes help your body recognize and fight germ...ImageRead Article Now Book Mark Article Tender lymph nodes Exams and Tests The provider can diagnose this condition by looking at the skin and rash. The liver, spleen, and lymph nodes may be swollen.The following tests may be done to confirm the diagnosis or rule out other conditions:Bilirubin level BilirubinThe bilirubin blood test measures the level of bilirubin in the blood. Bilirubin is a yellowish pigment found in bile, a fluid made by the liver. Bi...ImageRead Article Now Book Mark Article Hepatitis virus serology or hepatitis B surface antigen Hepatitis virus serologyThe hepatitis virus panel is a series of blood tests used to detect current or past infection by hepatitis A, hepatitis B, or hepatitis C. It can sc...ImageRead Article Now Book Mark Article Hepatitis B surface antigenThe hepatitis virus panel is a series of blood tests used to detect current or past infection by hepatitis A, hepatitis B, or hepatitis C. It can sc...ImageRead Article Now Book Mark Article Liver enzymes (liver function tests) Liver function testsLiver function tests are common tests that are used to see how well the liver is working. Tests include:AlbuminAlpha-1 antitrypsinAlkaline phosphata...ImageRead Article Now Book Mark Article Screening for EBV antibodies EBV antibodiesEpstein-Barr virus antibody test is a blood test to detect antibodies to the Epstein-Barr virus (EBV), which is a cause of the infection mononucleosi...ImageRead Article Now Book Mark Article Skin biopsySkin biopsyA skin lesion biopsy is when a small amount of skin is removed so it can be examined. The skin is tested to look for skin conditions or diseases. A...ImageRead Article Now Book Mark Article Treatment The disorder itself is not treated. Infections linked with this condition, such as hepatitis B and Epstein-Barr, are treated. Cortisone creams and oral antihistamines may help with itching and irritation. Outlook (Prognosis) The rash usually disappears on its own in about 3 to 8 weeks without treatment or complication. Associated conditions must be watched carefully. Possible Complications Complications occur as a result of associated conditions, rather than as a result of the rash. When to Contact a Medical Professional Call your provider if your child has signs of this condition.Open ReferencesReferencesBender NR, Chiu YE. Eczematous disorders. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 674.Gelmetti C. Gianotti-Crosti syndrome. In: Lebwohl MG, Heymann WR, Berth-Jones J, Coulson IH, eds. Treatment of Skin Disease: Comprehensive Therapeutic Strategies. 5th ed. Philadelphia, PA: Elsevier; 2018:chap 91.AllVideoImagesTogGianotti-Crosti syndrome on the leg - illustration Gianotti-Crosti disease is also called acrodermatitis of childhood. These red, elevated lesions do not contain pus and can occur on the limbs, buttocks, face, and neck.Gianotti-Crosti syndrome on the legillustrationInfectious mononucleosis - illustration Swollen lymph nodes, sore throat, fatigue and headache are some of the symptoms of mononucleosis, which is caused by the Epstein-Barr virus. It is generally self-limiting and most patients can recover in 4 to 6 weeks without medicines.Infectious mononucleosisillustrationGianotti-Crosti syndrome on the leg - illustration Gianotti-Crosti disease is also called acrodermatitis of childhood. These red, elevated lesions do not contain pus and can occur on the limbs, buttocks, face, and neck.Gianotti-Crosti syndrome on the legillustrationInfectious mononucleosis - illustration Swollen lymph nodes, sore throat, fatigue and headache are some of the symptoms of mononucleosis, which is caused by the Epstein-Barr virus. It is generally self-limiting and most patients can recover in 4 to 6 weeks without medicines.Infectious mononucleosisillustrationRelated Information Fever(Symptoms)Malaise(Symptoms)Hepatitis B(Condition)Papule(Symptoms)Rashes(Symptoms)Hepatitis(In-Depth) Review Date: 4/14/2021 Reviewed By: Elika Hoss, MD, Senior Associate Consultant, Mayo Clinic, Scottsdale, AZ. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- © 1997- All rights reserved. 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