BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuAutosomal dominantInheritance - autosomal dominant; Genetics - autosomal dominantAutosomal dominant is one of many ways that a trait or disorder can be passed down through families.In an autosomal dominant disease, if you get the abnormal gene from only one parent, you can get the disease. Often, one of the parents may also have the disease.GeneA gene is a short piece of DNA. Genes tell the body how to build specific proteins. There are about 20,000 genes in each cell of the human body. T...ImageRead Article Now Book Mark Article Information Inheriting a disease, condition, or trait depends on the type of chromosome affected (nonsex or sex chromosome). It also depends on whether the trait is dominant or recessive.Sex chromosomeSex-linked dominant is a rare way that a trait or disorder can be passed down through families. One abnormal gene on the X chromosome can cause a se...ImageRead Article Now Book Mark Article A single abnormal gene on one of the first 22 nonsex (autosomal) chromosomes from either parent can cause an autosomal disorder.AutosomalChromosomes are structures found in the center (nucleus) of cells that carry long pieces of DNA. DNA is the material that holds genes. It is the bu...ImageRead Article Now Book Mark Article Dominant inheritance means an abnormal gene from one parent can cause disease. This happens even when the matching gene from the other parent is normal. The abnormal gene dominates.This disease can also occur as a new condition in a child when neither parent has the abnormal gene.A parent with an autosomal dominant condition has a 50% chance of having a child with the condition. This is true for each pregnancy.It means that each child's risk for the disease does not depend on whether their sibling has the disease.Children who do not inherit the abnormal gene will not develop or pass on the disease.If someone is diagnosed with an autosomal dominant disease, their parents should also be tested for the abnormal gene.Examples of autosomal dominant disorders include Marfan syndrome and neurofibromatosis type 1. Marfan syndromeMarfan syndrome is a disorder of connective tissue. This is the tissue that strengthens the body's structures. Disorders of connective tissue affect...ImageRead Article Now Book Mark Article Neurofibromatosis type 1Neurofibromatosis-1 (NF1) is an inherited disorder in which nerve tissue tumors (neurofibromas) form in the:Upper and lower layers of the skinNerves ...ImageRead Article Now Book Mark Article Open ReferencesReferencesJones KL, Jones MC, Campo M. Genetics, genetic counseling, and prevention. In: Jones KL, Jones MC, Campo MD, eds. Smith's Recognizable Patterns of Human Deformation. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 2.Nussbaum RL, McInnes RR, Willard HF. Patterns of single-gene inheritance. In: Nussbaum RL, McInnes RR, Willard HF, eds. Thompson & Thompson Genetics in Medicine. 8th ed. Philadelphia, PA: Elsevier; 2016:chap 7.Scott DA, Lee B. Patterns of genetic transmission. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson Textbook of Pediatrics. 21st ed. Philadelphia, PA: Elsevier; 2020:chap 97.AllVideoImagesTogAutosomal dominant genes - illustration In the case of autosomal dominant genes, a single abnormal gene on one of the autosomal chromosomes (one of the first 22 non-sex chromosomes) from either parent can cause the disease. One of the parents will have the disease (since it is dominant) in this mode of inheritance and that person is called the CARRIER. Only one parent must be a carrier in order for the child to inherit the disease.Autosomal dominant genesillustrationAutosomal dominant genes - illustration In the case of autosomal dominant genes, a single abnormal gene on one of the autosomal chromosomes (one of the first 22 non-sex chromosomes) from either parent can cause the disease. One of the parents will have the disease (since it is dominant) in this mode of inheritance and that person is called the CARRIER. Only one parent must be a carrier in order for the child to inherit the disease.Autosomal dominant genesillustrationRelated Information Genes(Special Topic)Chromosome(Special Topic)Genetics(Special Topic) Review Date: 1/6/2022 Reviewed By: Anna C. Edens Hurst, MD, MS, Associate Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. 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