BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuAmitriptyline and perphenazine overdoseTriptazine overdoseAmitriptyline and perphenazine is a combination drug. It is sometimes prescribed for people with depression, agitation, or anxiety.Amitriptyline and perphenazine overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose.This article is for information only. DO NOT use it to treat or manage an actual overdose. If you or someone you are with has an overdose, call the local emergency number (such as 911), or the local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States.OverdoseAn overdose is when you take more than the normal or recommended amount of something, often a drug. An overdose may result in serious, harmful sympt...Read Article Now Book Mark Article Poisonous Ingredient Amitriptyline and perphenazine can be very harmful in large amounts. Where Found Medicines with this brand name contain amitriptyline and perphenazine:TriptazineOther medicines may also contain amitriptyline and perphenazine. Symptoms Below are symptoms of an amitriptyline and perphenazine overdose in different parts of the body. These symptoms may occur more often or be more severe in people who also take certain other medicines that affect serotonin, a chemical in the brain.AIRWAYS AND LUNGSSlowed, labored breathing Slowed, labored breathingBreathing difficulty may involve:Difficult breathing Uncomfortable breathingFeeling like you are not getting enough airRead Article Now Book Mark Article No breathingBLADDER AND KIDNEYSHard to start urinating, and urine stream may be weak Hard to start urinatingDifficulty starting or maintaining a urine stream is called urinary hesitancy.Read Article Now Book Mark Article Inability to completely empty the bladderEYES, EARS, NOSE, THROAT, AND MOUTHBlurred vision Blurred visionThere are many types of eye problems and vision disturbances, such as: Halos Blurred vision (the loss of sharpness of vision and the inability to see...Read Article Now Book Mark Article Dry mouth Enlarged pupils Eye pain in people at risk for a type of glaucoma Nasal congestion Nasal congestionA stuffy or congested nose occurs when the tissues lining it become swollen. The swelling is due to inflamed blood vessels. The problem may also in...Read Article Now Book Mark Article Unpleasant taste in mouthHEART AND BLOODIrregular heartbeat Irregular heartbeatPalpitations are feelings or sensations that your heart is pounding or racing. They can be felt in your chest, throat, or neck. You may:Have an unpl...Read Article Now Book Mark Article Low blood pressure (severe) Rapid heartbeat Rapid heartbeatPalpitations are feelings or sensations that your heart is pounding or racing. They can be felt in your chest, throat, or neck. You may:Have an unpl...Read Article Now Book Mark Article ShockShockShock is a life-threatening condition that occurs when the body is not getting enough blood flow. Lack of blood flow means the cells and organs do n...Read Article Now Book Mark Article MUSCLES AND JOINTSMuscles are rigid Muscles are rigidMuscle cramps are when a muscle gets tight (contracts) without you trying to tighten it, and it does not relax. Cramps may involve all or part of on...Read Article Now Book Mark Article Muscle spasms or stiffness of the limbs Muscle spasmsMuscle cramps are when a muscle gets tight (contracts) without you trying to tighten it, and it does not relax. Cramps may involve all or part of on...Read Article Now Book Mark Article Stiff muscles in neck, face, or backStiff muscles in neck, face, or backJoint pain can affect one or more joints.Read Article Now Book Mark Article NERVOUS SYSTEMAgitation AgitationAgitation is an unpleasant state of extreme arousal. An agitated person may feel stirred up, excited, tense, confused, or irritable.Read Article Now Book Mark Article Coma (decreased level of consciousness and lack of responsiveness) ComaDecreased alertness is the most severe state of reduced awareness and is a serious condition. A coma is a state of decreased alertness from which a p...Read Article Now Book Mark Article Seizures SeizuresA seizure is the physical changes in behavior that occurs during an episode of abnormal electrical activity in the brain. The term "seizure" is often...Read Article Now Book Mark Article Delirium Disorientation Drowsiness DrowsinessDrowsiness refers to feeling more sleepy than normal during the day. People who are drowsy may fall asleep in when they do not want to or at times w...Read Article Now Book Mark Article Lower than normal body temperature Lower than normal body temperatureHypothermia is dangerously low body temperature, below 95°F (35°C).Read Article Now Book Mark Article Restlessness RestlessnessAgitation is an unpleasant state of extreme arousal. An agitated person may feel stirred up, excited, tense, confused, or irritable.Read Article Now Book Mark Article Uncoordinated movement Uncoordinated movementUncoordinated movement is due to a muscle control problem that causes an inability to coordinate movements. It leads to a jerky, unsteady, to-and-fr...Read Article Now Book Mark Article Tremor WeaknessREPRODUCTIVE SYSTEMChange in menstrual patternsSKINItchy skin ItchyItching is a tingling or irritation of the skin that makes you want to scratch the area. Itching may occur all over the body or only in one location...Read Article Now Book Mark Article RashRashRashes involve changes in the color, feeling or texture of your skin.Read Article Now Book Mark Article STOMACH AND INTESTINESConstipation ConstipationConstipation in infants and children occurs when they have hard stools or have problems passing stools. A child may have pain while passing stools o...Read Article Now Book Mark Article Loss of appetite Loss of appetiteA decreased appetite is when your desire to eat is reduced. The medical term for a loss of appetite is anorexia.Read Article Now Book Mark Article Nausea and vomiting Before Calling Emergency Have this information ready: Person's age, weight, and condition Name of the product (ingredients and strength, if known) Time it was swallowed Amount swallowed If the medicine was prescribed for the person Poison Control Your local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This national hotline number will let you talk to experts in poisoning. They will give you further instructions.Poison control centerFor a POISON EMERGENCY call:1-800-222-1222ANYWHERE IN THE UNITED STATESThis national hotline number will let you talk to experts in poisoning. This ...Read Article Now Book Mark Article This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week. What to Expect at the Emergency Room Take the container to the hospital with you, if possible.The health care provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure.Tests that may done include:Blood and urine tests Chest x-ray ECG (electrocardiogram, or heart tracing)Treatment may include:Fluids through a vein (by IV) Medicines to treat symptoms Activated charcoal Laxative Breathing support, including a tube through the mouth into the lungs and connected to a breathing machine (ventilator) Outlook (Prognosis) An overdose of amitriptyline and perphenazine can be very serious.People who overdose on this drug are almost always admitted to the hospital.How well someone does depends on how much of the drug they swallowed and how quickly receive treatment is received. The faster medical help is given, the better the chance of recovery. Complications such as pneumonia, muscle damage from lying on a hard surface for a long period of time, or brain damage from lack of oxygen may result in permanent disability. Death can occur.Open ReferencesReferencesAronson JK. Tricyclic antidepressants. In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:146-169.Huffman JC, Beach SR, Stern TA. Side effects of psychotropic medications. In: Stern TA, Fava M, Wilens TE, Rosenbaum JF, eds. Massachusetts General Hospital Psychopharmacology and Neurotherapeutics. Philadelphia, PA: Elsevier; 2016:chap 12.Levine MD, Ruha A-M. Antidepressants. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 146.AllVideoImagesTogRelated Information Review Date: 11/13/2021 Reviewed By: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. 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