BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuPyruvate kinase blood testThe pyruvate kinase test measures the level of the enzyme pyruvate kinase in the blood.Pyruvate kinase is an enzyme found in red blood cells. It helps change sugar in the blood (glucose) to energy when oxygen levels are low.EnzymeEnzymes are complex proteins that cause a specific chemical change in all parts of the body. For example, they can help break down the foods we eat ...Read Article Now Book Mark Article How the Test is Performed A blood sample is needed. In the laboratory, white blood cells are removed from the blood sample because they can alter test results. The level of pyruvate kinase is then measured.Blood sampleVenipuncture is the collection of blood from a vein. It is most often done for laboratory testing.Read Article Now Book Mark Article How to Prepare for the Test No special preparation is necessary.If your child is having this test, it may help to explain how the test will feel and even demonstrate on a doll. Explain the reason for the test. Knowing the "how and why" may reduce your child's anxiety. How the Test will Feel When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away. Why the Test is Performed This test is done to detect an abnormally low level of pyruvate kinase. Without enough of this enzyme, red blood cells break down faster than normal. This is called hemolytic anemia. Hemolytic anemiaAnemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body tissues. Normally, red ...Read Article Now Book Mark Article This test helps diagnose pyruvate kinase deficiency (PKD).Pyruvate kinase deficiency (PKD)Pyruvate kinase deficiency is an inherited lack of the enzyme pyruvate kinase, which is used by red blood cells. Without this enzyme, red blood cell...Read Article Now Book Mark Article Normal Results Results vary depending on the testing method used. In general, a normal value is 179 ± 16 units per 100 mL of red blood cells.Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your health care provider about the meaning of your specific test results. What Abnormal Results Mean A low level of pyruvate kinase confirms PKD. Risks There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.Other risks associated with having blood drawn are slight, but may include:Excessive bleeding Fainting or feeling lightheaded Multiple punctures to locate veins Hematoma (blood buildup under the skin) Infection (a slight risk any time the skin is broken) Open ReferencesReferencesElghetany MT, Schexneider KI, Banki K. Erythrocytic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. St Louis, MO: Elsevier; 2017:chap 32.Gallagher PG. Hemolytic anemias: red cell membrane and metabolic defects. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 152.Papachristodoulou D. Energy metabolism. In: Naish J, Syndercombe Court D, eds. Medical Sciences. 3rd ed. Philadelphia, PA: Elsevier; 2019:chap 3.van Solinge WW, van Wijk R. Enzymes of the red blood cell. In: Rifai N, ed. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Philadelphia, PA: Elsevier; 2018:chap 30.AllVideoImagesTog Tests for Pyruvate kinase blood test Pyruvate kinase blood testRelated Information Enzyme(Special Topic)Metabolism(Special Topic)Hemolytic anemia(Condition)Anemia(Condition)Anemia(In-Depth) Review Date: 2/6/2020 Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- © 1997- All rights reserved. A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.Content is best viewed in IE9 or above, Firefox and Google Chrome browser.