BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuSerum globulin electrophoresisQuantitative immunoglobulinsThe serum globulin electrophoresis test measures the levels of proteins called globulins in the fluid part of a blood sample. This fluid is called serum. How the Test is Performed A blood sample is needed.Blood sampleVenipuncture is the collection of blood from a vein. It is most often done for laboratory testing.ImageRead Article Now Book Mark Article In the lab, the technician places the blood sample on special paper and applies an electric current. The proteins move on the paper and form bands that show the amount of each protein. How to Prepare for the Test Follow instructions on whether or not you need to fast before this test.Certain medicines may affect the results of this test. Your health care provider will tell you if you need to stop taking any medicines. Do not stop any medicine before talking to your provider. How the Test will Feel When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away. Why the Test is Performed This test is done to look at globulin proteins in the blood. Identifying the types of globulins can help diagnose certain medical problems.Globulins are roughly divided into three groups: alpha, beta, and gamma globulins. Gamma globulins include various types of antibodies such as immunoglobulins (Ig) M, G, and A.Certain diseases are associated with producing too many immunoglobulins. For example, Waldenstrom macroglobulinemia is a cancer of certain white blood cells. It is linked with producing too many IgM antibodies.Waldenstrom macroglobulinemiaWaldenström macroglobulinemia (WM) is a cancer of the B lymphocytes (a type of white blood cell). WM is associated with the overproduction of protei...ImageRead Article Now Book Mark Article Normal Results Normal value ranges are:Serum globulin: 2.0 to 3.5 grams per deciliter (g/dL) or 20 to 35 grams per liter (g/L) IgM component: 75 to 300 milligrams per deciliter (mg/dL) or 750 to 3,000 milligrams per liter (mg/L) IgG component: 650 to 1,850 mg/dL or 6.5 to 18.50 g/L IgA component: 90 to 350 mg/dL or 900 to 3,500 mg/LNormal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results. What Abnormal Results Mean Increased gamma globulin proteins may indicate:Acute infection AcuteAcute means sudden or severe. Acute symptoms appear, change, or worsen rapidly. It is the opposite of chronic.ImageRead Article Now Book Mark Article Blood and bone marrow cancers including multiple myeloma, and some lymphomas and leukemias Multiple myelomaMultiple myeloma is a blood cancer that starts in the plasma cells in the bone marrow. Bone marrow is the soft, spongy tissue found inside most bone...ImageRead Article Now Book Mark Article Immune deficiency disorders Immune deficiency disordersImmunodeficiency disorders occur when the body's immune response is reduced or absent.ImageRead Article Now Book Mark Article Long-term (chronic) inflammatory disease (for example, rheumatoid arthritis and systemic lupus erythematosus) ChronicChronic refers to something that continues over an extended period of time. A chronic condition is usually long-lasting and does not easily or quick...ImageRead Article Now Book Mark Article Rheumatoid arthritisRheumatoid arthritis (RA) is a disease that leads to inflammation of the joints and surrounding tissues. It is a long-term disease. It can also aff...ImageRead Article Now Book Mark Article Systemic lupus erythematosusSystemic lupus erythematosus (SLE) is an autoimmune disease. In this disease, the immune system of the body mistakenly attacks healthy tissue. It c...ImageRead Article Now Book Mark Article Waldenström macroglobulinemiaWaldenström macroglobulinemiaWaldenström macroglobulinemia (WM) is a cancer of the B lymphocytes (a type of white blood cell). WM is associated with the overproduction of protei...ImageRead Article Now Book Mark Article Risks There is very little risk involved with having your blood taken. Veins and arteries vary in size from one person to another, and from one side of the body to the other. Taking blood from some people may be more difficult than from others.Other risks associated with having blood drawn are slight, but may include:Excessive bleeding Fainting or feeling lightheaded Multiple punctures to locate veins Hematoma (blood buildup under the skin) Infection (a slight risk any time the skin is broken) Open ReferencesReferencesChernecky CC, Berger BJ. Immunoelectrophoresis - serum and urine. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:667-692.Dominiczak MH, Fraser WD. Blood and plasma proteins. In: Baynes JW, Dominiczak MH, eds. Medical Biochemistry. 5th ed. Philadelphia, PA: Elsevier; 2019:chap 40.AllVideoImagesTogBlood test - illustration Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.Blood testillustrationBlood test - illustration Blood is drawn from a vein (venipuncture), usually from the inside of the elbow or the back of the hand. A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. Preparation may vary depending on the specific test.Blood testillustration Tests for Serum globulin electrophoresis Serum globulin electrophoresisImmunoelectrophoresis - bloodProtein electrophoresis - serumRelated Information Protein electrophoresis - serum(Medical Test)Immunoelectrophoresis - blood(Medical Test)Amino acids(Special Topic)Hemoglobin(Medical Test)Fibrinogen blood test(Medical Test)Antibody(Special Topic)Albumin blood (serum) test(Medical Test)Total protein(Medical Test)Multiple myeloma(Condition)Chronic(Special Topic)Cholesterol(In-Depth)Rheumatoid arthritis(In-Depth)Systemic lupus erythematosus(In-Depth) Review Date: 2/6/2020 Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. 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