BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuLeucine aminopeptidase - urineLeucine aminopeptidase is a type of protein called an enzyme. It is normally found in liver cells and cells of the small intestine. This test is used to measure how much of this protein appears in your urine.Your blood can also be checked for this protein.ProteinThe leucine aminopeptidase (LAP) test measures how much of this enzyme is in your blood. Your urine can also be checked for LAP.ImageRead Article Now Book Mark Article How the Test is Performed A 24-hour urine sample is needed.On day 1, urinate into the toilet when you get up in the morning. Afterward, collect all urine in a special container for the next 24 hours. On day 2, urinate into the container when you get up in the morning. Cap the container. Keep it in the refrigerator or a cool place during the collection period.Label the container with your name, the date, the time of completion, and return it as instructed.For an infant, thoroughly wash the area where urine exits the body.Open a urine collection bag (a plastic bag with an adhesive paper on one end). For males, place the entire penis in the bag and attach the adhesive to the skin. For females, place the bag over the labia. Diaper as usual over the secured bag.This procedure may take more than one try. An active infant can move the bag, so that the urine leaks into the diaper.Check the infant often and change the bag after the infant has urinated into it.Drain the urine from the bag into the container given to you by your health care provider. Deliver the sample to the laboratory or your provider as soon as possible.Your provider will tell you, if needed, to stop taking drugs that may interfere with the test. How to Prepare for the Test Your provider may tell you to stop taking any medicines that could affect the test. Drugs that can affect the results of this test include estrogen and progesterone. Never stop taking any medicine without first talking to your provider. How the Test will Feel The test involves only normal urination. There is no discomfort. Why the Test is Performed You may need this test to see if there is liver damage. It may also be done to check for certain tumors.This test is only rarely done. Other tests such as gamma glutamyl transpeptidase are more accurate and easily available. Normal Results Normal values range from 2 to 18 units per 24 hours.Normal value ranges may vary slightly among different laboratories. Talk to your provider about the meaning of your specific test results.The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens. What Abnormal Results Mean Increased levels of leucine aminopeptidase can be seen in several conditions:Cholestasis CholestasisCholestasis is any condition in which the flow of bile from the liver is slowed or blocked.ImageRead Article Now Book Mark Article Cirrhosis CirrhosisCirrhosis is scarring of the liver and poor liver function. It is the last stage of chronic liver disease.ImageRead Article Now Book Mark Article Hepatitis HepatitisHepatitis is swelling and inflammation of the liver.ImageRead Article Now Book Mark Article Liver cancer Liver cancerHepatocellular carcinoma is cancer that starts in the liver.ImageRead Article Now Book Mark Article Liver ischemia (reduced blood flow to the liver) Liver necrosis (death of liver tissue) NecrosisNecrosis is the death of body tissue. It occurs when too little blood flows to the tissue. This can be from injury, radiation, or chemicals. Necro...ImageRead Article Now Book Mark Article Liver tumor Liver tumorHepatocellular carcinoma is cancer that starts in the liver.ImageRead Article Now Book Mark Article Pregnancy (late stage) Risks There is no real risk.Open ReferencesReferencesChernecky CC, Berger BJ. Trypsin- plasma or serum. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:1126.Daniels L, Khalili M, Goldstein E, Bluth MH, Bowne WB, Pincus MR. Evaluation of liver function. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 22.Korenblat KM, Berk PD. Approach to the patient with jaundice or abnormal liver tests. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 138.AllVideoImagesTogCirrhosis of the liver - illustration A chronic liver disease which causes damage to liver tissue, scarring of the liver (fibrosis; nodular regeneration), progressive decrease in liver function, excessive fluid in the abdomen (ascites), bleeding disorders (coagulopathy), increased pressure in the blood vessels (portal hypertension), and brain function disorders (hepatic encephalopathy). Excessive alcohol use is the leading cause of cirrhosis.Cirrhosis of the liverillustrationLeucine aminopeptidase urine test - illustration Leucine aminopeptidase (LAP) is a proteolytic enzyme that breaks chemical bonds in proteins at specific sites next to leucine amino acids. Serum (blood) LAP is measured to diagnose liver (hepatic) dysfunction.Leucine aminopeptidase urine testillustrationCirrhosis of the liver - illustration A chronic liver disease which causes damage to liver tissue, scarring of the liver (fibrosis; nodular regeneration), progressive decrease in liver function, excessive fluid in the abdomen (ascites), bleeding disorders (coagulopathy), increased pressure in the blood vessels (portal hypertension), and brain function disorders (hepatic encephalopathy). Excessive alcohol use is the leading cause of cirrhosis.Cirrhosis of the liverillustrationLeucine aminopeptidase urine test - illustration Leucine aminopeptidase (LAP) is a proteolytic enzyme that breaks chemical bonds in proteins at specific sites next to leucine amino acids. Serum (blood) LAP is measured to diagnose liver (hepatic) dysfunction.Leucine aminopeptidase urine testillustration Tests for Leucine aminopeptidase - urine Leucine aminopeptidase - urineUrine chemistryLeucine aminopeptidase blood testRelated Information Leucine aminopeptidase blood test(Medical Test)Enzyme(Special Topic)Protein in diet(Nutrition)Amino acids(Special Topic)Cholestasis(Condition)Cirrhosis(Condition)Hepatic(Special Topic)Necrosis(Special Topic)Liver cancer - hepatocellular carcinoma(Condition)Hepatitis(Condition)Cirrhosis(In-Depth)Hepatitis(In-Depth) Review Date: 1/14/2021 Reviewed By: Michael M. Phillips, MD, Emeritus Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. 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