BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuDonath-Landsteiner testAnti-P antibody; Paroxysmal cold hemoglobinuria - Donath-LandsteinerThe Donath-Landsteiner test is a blood test to detect harmful antibodies related to a rare disorder called paroxysmal cold hemoglobinuria. These antibodies form and destroy red blood cells when the body is exposed to cold temperatures.AntibodiesAn antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include micr...Read Article Now Book Mark Article Paroxysmal cold hemoglobinuriaParoxysmal cold hemoglobinuria (PCH) is a rare blood disorder in which the body's immune system produces antibodies that destroy red blood cells. It...Read Article Now Book Mark Article How the Test is Performed A blood sample is needed.Blood sampleVenipuncture is the collection of blood from a vein. It is most often done for laboratory testing.Read Article Now Book Mark Article How to Prepare for the Test No special preparation is needed. How the Test will Feel When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away. Why the Test is Performed This test is done to confirm a diagnosis of paroxysmal cold hemoglobinuria. Normal Results The test is considered normal if no Donath-Landsteiner antibodies are present. This is called a negative result.Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your health care provider about the meaning of your specific test results. What Abnormal Results Mean Abnormal results mean Donath-Landsteiner antibodies are present. This is a sign of paroxysmal cold hemoglobinuria. Risks There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.Other risks associated with having blood drawn are slight, but may include:Excessive bleeding Fainting or feeling lightheaded Multiple punctures to locate veins Hematoma (blood buildup under the skin) Infection (a slight risk any time the skin is broken) Open ReferencesReferencesElghetany MT, Schexneider KI, Banki K. Erythrocytic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. St Louis, MO: Elsevier; 2017:chap 32.Michel M. Autoimmune and intravascular hemolytic anemias. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 151.AllVideoImagesTog Tests for Donath-Landsteiner test Donath-Landsteiner testRelated Information Antibody(Special Topic)Paroxysmal cold hemoglobinuria (PCH)(Condition)Complement(Medical Test)Measles(Condition)Mumps(Condition) Review Date: 2/6/2020 Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- © 1997- All rights reserved. A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.Content is best viewed in IE9 or above, Firefox and Google Chrome browser.