BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuEstradiol blood testE2 testAn estradiol test measures the amount of a hormone called estradiol in the blood. Estradiol is one of the main types of estrogens. How the Test is Performed A blood sample is needed.Blood sample is neededVenipuncture is the collection of blood from a vein. It is most often done for laboratory testing.Read Article Now Book Mark Article How to Prepare for the Test Your health care provider may tell you to temporarily stop taking certain medicines that may affect test results. Be sure to tell your provider about all the medicines you take. These include:Birth control pills Antibiotics such as ampicillin or tetracycline Corticosteroids DHEA (a supplement) Estrogen Medicine to manage mental disorders (such as phenothiazine) Testosterone Do not stop taking any medicine before talking to your doctor. How the Test will Feel When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging. Afterward, there may be some throbbing or a slight bruise. This soon goes away. Why the Test is Performed In women, most estradiol is released from the ovaries and adrenal glands. It is also released by the placenta during pregnancy. Estradiol is also produced in other body tissues, such as skin, fat, cells bone, brain, and liver. Estradiol plays a role in: Growth of the womb (uterus), fallopian tubes, and vagina Breast development Changes of the outer genitals Distribution of body fat Menopause In men, a small amount of estradiol is mainly released by the testes. Estradiol helps prevent sperm from dying too early. This test may be ordered to check:How well your ovaries, placenta, or adrenal glands work If you have signs of an ovarian tumor If male or female body characteristics are not developing normally If your periods have stopped (levels of estradiol vary, depending on the time of month) The test may also be ordered to check if:Hormone therapy is working for women in menopause MenopauseMenopause is the time in a woman's life when her periods (menstruation) stop. Most often, it is a natural, normal body change that most often occurs...Read Article Now Book Mark Article A woman is responding to fertility treatment The test may also be used to monitor people with hypopituitarism and women on certain fertility treatments.HypopituitarismHypopituitarism is a condition in which the pituitary gland does not produce normal amounts of some or all of its hormones.Read Article Now Book Mark Article Normal Results The results may vary, depending on the person's sex and age.Male: 10 to 50 pg/mL (36.7 to 183.6 pmol/L) Female (premenopausal): 30 to 400 pg/mL (110 to 1468.4 pmol/L) Female (postmenopausal): 0 to 30 pg/mL (0 to 110 pmol/L) Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your doctor about the meaning of your specific test result. What Abnormal Results Mean Disorders that are associated with abnormal estradiol results include:Early (precocious) puberty in girls Early (precocious) pubertyPuberty is the time when a person's sexual and physical characteristics mature. Precocious puberty is when these body changes happen earlier than no...Read Article Now Book Mark Article Growth of abnormally large breasts in men (gynecomastia) GynecomastiaWhen abnormal breast tissue develops in males, it is called gynecomastia. It is important to find out if the excess growth is breast tissue and not ...Read Article Now Book Mark Article Lack of periods in women (amenorrhea) AmenorrheaAbsence of a woman's monthly menstrual period is called amenorrhea. Primary amenorrhea is when a girl has not yet started her monthly periods, and sh...Read Article Now Book Mark Article Reduced function of the ovaries (ovarian hypofunction) Ovarian hypofunctionPremature ovarian failure is reduced function of the ovaries (including decreased production of hormones).Read Article Now Book Mark Article Problem with genes, such as Klinefelter syndrome, Turner syndrome Klinefelter syndromeKlinefelter syndrome is a genetic condition that occurs in males when they have an extra X chromosome.Read Article Now Book Mark Article Turner syndromeTurner syndrome is a rare genetic condition in which a female does not have the usual pair of X chromosomes.Read Article Now Book Mark Article Rapid weight loss or low body fat Risks There is little risk involved with having your blood taken. Veins and arteries vary in size from one person to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.Other risks associated with having blood drawn are slight, but may include:Excessive bleeding Fainting or feeling lightheaded Multiple punctures to locate veins Hematoma (blood accumulating under the skin) Infection (a slight risk any time the skin is broken) Open ReferencesReferencesGuber HA, Oprea M, Russell YX. Evaluation of endocrine function. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 25.Lobo RA. Primary and secondary amenorrhea and precocious puberty. In: Gershenson DM, Lentz GM, Valea FA, Lobo RA, eds. Comprehensive Gynecology. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 36.AllVideoImagesTogA Closer Look Coronary artery disease(In-Depth) Tests for Estradiol blood test Estradiol blood testLH response to GnRH blood testRelated Information Ovarian cancer(Condition)Vagina(Special Topic)Turner syndrome(Condition)Hypopituitarism(Condition)Ovarian cancer(In-Depth) Review Date: 7/13/2021 Reviewed By: John D. Jacobson, MD, Department of Obstetrics and Gynecology, Loma Linda University School of Medicine, Loma Linda, CA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. 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