BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuPleural needle biopsyClosed pleural biopsy; Needle biopsy of the pleuraPleural biopsy is a procedure to remove a sample of the pleura. This is the thin tissue that lines the chest cavity and surrounds the lungs. The biopsy is done to check the pleura for disease or infection. How the Test is Performed This test may be done in the hospital. It may also be done at a clinic or doctor's office.The procedure involves the following:You will be sitting up during the procedure. The health care provider cleanses the skin at the biopsy site. A numbing drug (anesthetic) is injected through the skin and into the lining of the lungs and chest wall (pleural membrane). A larger, hollow needle is then placed gently through the skin into the chest cavity. Sometimes, the provider uses ultrasound or CT imaging to guide the needle. UltrasoundUltrasound uses high-frequency sound waves to make images of organs and structures inside the body.ImageRead Article Now Book Mark Article CTA computed tomography (CT) scan is an imaging method that uses x-rays to create pictures of cross-sections of the body. Related tests include:Abdomin...ImageRead Article Now Book Mark Article A smaller cutting needle inside the hollow one is used to collect tissue samples. During this part of the procedure, you are asked to sing, hum, or say "eee." This helps prevent air from getting into the chest cavity, which can cause the lung to collapse (pneumothorax). Usually, 3 or more biopsy samples are taken. PneumothoraxA collapsed lung occurs when air escapes from the lung. The air then fills the space outside of the lung between the lung and chest wall. This buil...ImageRead Article Now Book Mark Article When the test is finished, a bandage is placed over the biopsy site. In recent years, pleural biopsy is most often done using a fiberoptic scope. The scope allows the provider to view the area of the pleura from which the biopsies are taken. How to Prepare for the Test You will have blood tests before the biopsy. You will likely have a chest x-ray.Chest x-rayA chest x-ray is an x-ray of the chest, lungs, heart, large arteries, ribs, and diaphragm.ImageRead Article Now Book Mark Article How the Test will Feel When the local anesthetic is injected, you may feel a brief prick and a burning sensation. When the biopsy needle is inserted, you may feel pressure. As the needle is being removed, you may feel tugging. Why the Test is Performed Pleural biopsy is often done to find the cause of a collection of fluid around the lung (pleural effusion) or other abnormality of the pleural membrane. Pleural biopsy can diagnose tuberculosis, cancer, and other diseases.Pleural effusionA pleural effusion is a buildup of fluid between the layers of tissue that line the lungs and chest cavity.ImageRead Article Now Book Mark Article TuberculosisPulmonary tuberculosis (TB) is a contagious bacterial infection that involves the lungs. It may spread to other organs.ImageRead Article Now Book Mark Article If this type of pleural biopsy is not enough to make a diagnosis, you may need a surgical biopsy of the pleura.Surgical biopsy of the pleuraAn open pleural biopsy is a procedure to remove and examine the tissue that lines the inside of the chest. This tissue is called the pleura....ImageRead Article Now Book Mark Article Normal Results Pleural tissues appear normal, without signs of inflammation, infection, or cancer. What Abnormal Results Mean Abnormal results may reveal: Primary lung cancer Primary lung cancerSmall cell lung cancer (SCLC) is a fast-growing type of lung cancer. It spreads much more quickly than non-small cell lung cancer. There are two typ...ImageRead Article Now Book Mark Article Malignant mesothelioma Malignant mesotheliomaMalignant mesothelioma is an uncommon cancerous tumor. It mainly affects the lining of the lung and chest cavity (pleura) or lining of the abdomen (...ImageRead Article Now Book Mark Article Metastatic pleural tumor Metastatic pleural tumorMetastatic pleural tumor is a type of cancer that has spread from another organ to the thin membrane (pleura) surrounding the lungs.ImageRead Article Now Book Mark Article Collagen vascular disease Tuberculosis Other infections Risks There is a slight chance of the needle puncturing the wall of the lung, which can partially collapse the lung. This usually gets better on its own. Sometimes, a chest tube is needed to drain the air and expand the lung. There is also a chance of excessive blood loss. Considerations If a closed pleural biopsy is not enough to make a diagnosis, you may need a surgical biopsy of the pleura. This procedure has been mostly replaced by a procedure that uses a scope to visualize the pleura while taking the biopsy.Open ReferencesReferencesReed JC. Pleural effusions. In: Reed JC, ed. Chest Radiology: Patterns and Differential Diagnoses. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 4.Walsh R, Klein JS. Thoracic radiology: invasive diagnostic imaging and image-guided interventions. In: Broaddus VC, Ernst JD, King TE, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. 6th ed. Philadelphia, PA: Elsevier; 2022:chap 21.AllVideoImagesTogPleural biopsy - illustration In a pleural biopsy, a small piece of pleural tissue in the chest is removed with a needle. The biopsy may distinguish between a cancerous and noncancerous disease. It also can help to detect whether a viral, fungal or parasitic disease is present.Pleural biopsyillustrationPleural biopsy - illustration In a pleural biopsy, a small piece of pleural tissue in the chest is removed with a needle. The biopsy may distinguish between a cancerous and noncancerous disease. It also can help to detect whether a viral, fungal or parasitic disease is present.Pleural biopsyillustration Tests for Pleural needle biopsy Pleural needle biopsyOpen pleural biopsyGram stainRelated Information Collagen vascular disease(Condition)Metastatic pleural tumor(Condition)Lung cancer - small cell(Condition) Review Date: 8/1/2021 Reviewed By: Denis Hadjiliadis, MD, MHS, Paul F. Harron Jr. Associate Professor of Medicine, Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. 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