BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuTests for H pyloriPeptic ulcer disease - H pylori; PUD - H pyloriHelicobacter pylori (H pylori) is the bacteria (germ) responsible for most stomach (gastric) and duodenal ulcers and many cases of stomach inflammation (chronic gastritis). How the Test is Performed There are several methods to test for H pylori infection.Breath Test (Carbon Isotope-urea Breath Test, or UBT)Up to 2 weeks before the test, you need to stop taking antibiotics, bismuth medicines such as Pepto-Bismol, and proton pump inhibitors (PPIs). During the test, you swallow a special substance that has urea. Urea is a waste product the body produces as it breaks down protein. The urea used in the test has been made harmlessly radioactive. If H pylori are present, the bacteria convert the urea into carbon dioxide, which is detected and recorded in your exhaled breath after 10 minutes. This test can identify almost all people who have H pylori. It can also be used to check that the infection has been fully treated. Blood TestsBlood tests are used to measure antibodies to H pylori. Antibodies are proteins made by the body's immune system when it detects harmful substances such as bacteria. AntibodiesAn antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include micr...Read Article Now Book Mark Article Blood tests for H pylori can only tell if your body has H pylori antibodies. It cannot tell if you have a current infection or how long you have had it. This is because the test can be positive for years, even if the infection is cured. As a result, blood tests cannot be used to see if the infection has been cured after treatment. Stool TestA stool test can detect traces of H pylori in the feces. This test can be used to diagnose the infection and confirm that it has been cured after treatment. Biopsy A tissue sample, called a biopsy, is taken from the stomach lining. This is the most accurate way to tell if you have an H pylori infection. BiopsyGastric tissue biopsy is the removal of stomach tissue for examination. A culture is a laboratory test that examines the tissue sample for bacteria ...Read Article Now Book Mark Article To remove the tissue sample, you have a procedure called endoscopy. The procedure is done in the hospital or outpatient center. EndoscopyEndoscopy is a way of looking inside the body using a flexible tube that has a small camera and light on the end of it. This instrument is called an...Read Article Now Book Mark Article Usually, a biopsy is done if endoscopy is needed for other reasons. Reasons include diagnosing the ulcer, treating bleeding, or making sure there is no cancer. Why the Test is Performed Testing is most often done to diagnose H pylori infection:If you currently have a stomach or duodenal ulcer If you had a stomach or duodenal ulcer in the past, and were never tested for H pylori After treatment for H pylori infection, to make sure there are no more of these bacteria Testing may also be done if you need to take long-term ibuprofen or other NSAID medicines. Your health care provider can tell you more.The test may also be recommended for a condition called dyspepsia (indigestion). This is upper abdominal discomfort. Symptoms include a feeling of fullness or of heat, burning, or pain in the area between the navel and the lower part of the breastbone during or after eating. Testing for H pylori without endoscopy is most often done only when the discomfort is new, the person is younger than 55, and there are no other symptoms. Normal Results Normal results mean there is no sign that you have an H pylori infection. What Abnormal Results Mean Abnormal results mean that you have an H pylori infection. Your provider will discuss treatment with you.Open ReferencesReferencesCover TL, Blaser MJ. Helicobacter pylori and other gastric Helicobacter species. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 217.Siddiqi HA, Rabinowitz S, Axiotis CA. Laboratory diagnosis of gastrointestinal and pancreatic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 23.AllVideoImagesTog Tests for Tests for H pylori Tests for H pyloriRelated Information Review Date: 7/1/2021 Reviewed By: Michael M. Phillips, MD, Emeritus Professor of Medicine, The George Washington University School of Medicine, Washington, DC. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- © 1997- All rights reserved. A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.Content is best viewed in IE9 or above, Firefox and Google Chrome browser.