BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuTargeted therapies for cancerMolecularly targeted anticancer agents; MTAs; Chemotherapy-targeted; Vascular endothelial growth factor-targeted; VEGF-targeted; VEGFR-targeted; Tyrosine kinase inhibitor-targeted; TKI-targeted; Personalized medicine - cancerTargeted therapy uses drugs to stop cancer from growing and spreading. It does this with less harm to normal cells than other treatments. Standard chemotherapy works by killings cancer cells and some normal cells, targeted treatment zeroes in on specific targets (molecules) in or on cancer cells. These targets play a role in how cancer cells grow and survive. Using these targets, the drug disables the cancer cells so they cannot spread.ChemotherapyThe term chemotherapy is used to describe cancer-killing drugs. Chemotherapy may be used to:Cure the cancer Shrink the cancerPrevent the cancer from...Read Article Now Book Mark Article How Does Targeted Therapy Work?Targeted therapy drugs work in a few different ways. They may:Turn off the process in cancer cells that causes them to grow and spread Trigger cancer cells to die on their own Kill cancer cells directly People with the same type of cancer may have different targets in their cancer cells. So, if your cancer does not have a specific target, the drug will not work to stop it. Not all therapies work for all people with cancer. At the same time, different cancers may have the same target.To see if a targeted therapy might work for you, your health care provider may:Take a tiny sample of your cancer Test the sample for the specific targets (molecules) If the right target is present in your cancer, then you will receive Some targeted therapies are given as pills. Others are injected into a vein (intravenous, or IV).Who May Get Targeted Therapy?Targeted therapies can treat most types of cancers.Your provider will decide whether targeted therapies may be an option for your type of cancer. You may receive targeted therapy along with surgery, chemotherapy, hormonal therapy, or radiation therapy. You may receive these drugs as part of your regular treatment, or as part of a clinical trial.Hormonal therapyHormone therapy to treat breast cancer uses drugs or treatments to lower levels or block the action of female sex hormones (estrogen and progesterone...Read Article Now Book Mark Article Radiation therapyRadiation therapy uses high-powered x-rays, particles, or radioactive seeds to kill cancer cells.Read Article Now Book Mark Article Clinical trialIf you have cancer, a clinical trial may be an option for you. A clinical trial is a study using people who agree to participate in new tests or tre...Read Article Now Book Mark Article Side EffectsDoctors thought that targeted therapies might have fewer side effects than other cancer treatments. But that turned out to be untrue. Possible side effects from targeted therapies include:Diarrhea Liver problems Skin problems such as rash, dry skin, and nail changes Problems with blood clotting and wound healing High blood pressure As with any treatment, you may or may not have side effects. They may be mild or severe. Fortunately, they usually go away after treatment ends. It is a good idea to talk with your provider about what to expect. Your provider may be able to help prevent or lessen some side effects.LimitationsTargeted therapies are promising new treatments, but they have limitations. Cancer cells can become resistant to these drugs. The target sometimes changes, so the treatment no longer works. The cancer may find a different way to grow and survive that does not depend on the target. Drugs can be difficult to develop for some targets. Targeted therapies are newer and cost more to make. So, they are more expensive than other cancer treatments. Open ReferencesReferencesDo KT, Kummar S. Therapeutic targeting of cancer cells: era of molecularly targeted agents. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 26.National Cancer Institute website. Targeted cancer therapies. www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet. Updated March 8, 2022. Accessed March 10, 2022.AllVideoImagesTogA Closer Look Breast cancer(In-Depth)Non-small cell lung cancer(In-Depth)Ovarian cancer(In-Depth)Colon and rectal cancers(In-Depth)Related Information Review Date: 10/28/2021 Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- © 1997- All rights reserved. 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