BACK TOTOP Browse A-ZSearchBrowse A-ZABCDEFGHIJKLMNOPQRSTUVWXYZ0-9 E-mail FormEmail ResultsName:Email address:Recipients Name:Recipients address:Message: Print-FriendlyBookmarksbookmarks-menuQuantitative Bence-Jones protein testImmunoglobulin light chains - urine; Urine Bence-Jones proteinThis test measures the level of abnormal proteins called Bence-Jones proteins in the urine. How the Test is Performed A clean-catch urine sample is needed. The clean-catch method is used to prevent germs from the penis or vagina from getting into a urine sample. To collect your urine, your health care provider may give you a special clean-catch kit that contains a cleansing solution and sterile wipes. Follow instructions exactly so that the results are accurate.Clean-catch urine sampleA clean catch is a method of collecting a urine sample to be tested. The clean-catch urine method is used to prevent germs from the penis or vagina ...ImageRead Article Now Book Mark Article The sample is sent to the lab. There are many methods used to detect Bence-Jones proteins. One method, called immunoelectrophoresis, is the most accurate.ImmunoelectrophoresisThe urine protein electrophoresis (UPEP) test is used to measure how much of certain proteins are in the urine.ImageRead Article Now Book Mark Article How the Test will Feel The test involves only normal urination, and there is no discomfort. Why the Test is Performed Bence-Jones proteins are a part of regular antibodies called light chains. These proteins are not normally in urine. Sometimes, when your body makes too many antibodies, the level of light chains also rises. Bence-Jones proteins are small enough to be filtered out by the kidneys. The proteins then spill into the urine. AntibodiesAn antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include micr...ImageRead Article Now Book Mark Article Your provider may order this test:To diagnose conditions that lead to protein in the urine If you have a lot of protein in your urine If you have signs of a blood cancer called multiple myelomaMultiple myelomaMultiple myeloma is a blood cancer that starts from a type of white blood cell in the bone marrow called plasma cells. Bone marrow is the soft, spon...ImageRead Article Now Book Mark Article Normal Results A normal result means no Bence-Jones proteins are found in your urine. What Abnormal Results Mean Bence-Jones proteins are rarely found in urine. If they are, it is usually associated with multiple myeloma.Multiple myelomaMultiple myeloma is a blood cancer that starts from a type of white blood cell in the bone marrow called plasma cells. Bone marrow is the soft, spon...ImageRead Article Now Book Mark Article An abnormal result may also be due to:An abnormal buildup of proteins in tissues and organs (amyloidosis) AmyloidosisPrimary amyloidosis is a rare disorder in which abnormal proteins build up in tissues and organs. Clumps of the abnormal proteins are called amyloid...ImageRead Article Now Book Mark Article Blood cancer called chronic lymphocytic leukemia Chronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL) is cancer of a type of white blood cells called lymphocytes. These cells are found in the bone marrow and other p...ImageRead Article Now Book Mark Article Lymph system cancer (lymphoma) Buildup in the blood of a protein called M-protein (monoclonal gammopathy of unknown significance; MGUS) Chronic renal failureChronic renal failureChronic kidney disease is the slow loss of kidney function over time. The main job of the kidneys is to remove wastes and excess water from the body...ImageRead Article Now Book Mark Article Risks There are no risks with this test.Open ReferencesReferencesGertz MA, Dispenzieri A. Amyloidosis. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 174.Rajkumar SV, Dispenzieri A. Multiple myeloma and related disorders. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 101. Riley RS, McPherson RA. Basic examination of urine. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 29.AllVideoImagesTogMale urinary system - illustration The urinary system is made up of the kidneys, ureters, urethra and bladder.Male urinary systemillustrationMale urinary system - illustration The urinary system is made up of the kidneys, ureters, urethra and bladder.Male urinary systemillustration Tests for Quantitative Bence-Jones protein test Quantitative Bence-Jones protein testRelated Information Antibody(Special Topic)Waldenstrom macroglobulinemia(Condition)Chronic lymphocytic leukemia (CLL)(Condition)Primary amyloidosis(Condition) Review Date: 6/17/2024 Reviewed By: Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. 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Quantitative Bence-Jones protein testImmunoglobulin light chains - urine; Urine Bence-Jones proteinThis test measures the level of abnormal proteins called Bence-Jones proteins in the urine. How the Test is Performed A clean-catch urine sample is needed. The clean-catch method is used to prevent germs from the penis or vagina from getting into a urine sample. To collect your urine, your health care provider may give you a special clean-catch kit that contains a cleansing solution and sterile wipes. Follow instructions exactly so that the results are accurate.Clean-catch urine sampleA clean catch is a method of collecting a urine sample to be tested. The clean-catch urine method is used to prevent germs from the penis or vagina ...ImageRead Article Now Book Mark Article The sample is sent to the lab. There are many methods used to detect Bence-Jones proteins. One method, called immunoelectrophoresis, is the most accurate.ImmunoelectrophoresisThe urine protein electrophoresis (UPEP) test is used to measure how much of certain proteins are in the urine.ImageRead Article Now Book Mark Article How the Test will Feel The test involves only normal urination, and there is no discomfort. Why the Test is Performed Bence-Jones proteins are a part of regular antibodies called light chains. These proteins are not normally in urine. Sometimes, when your body makes too many antibodies, the level of light chains also rises. Bence-Jones proteins are small enough to be filtered out by the kidneys. The proteins then spill into the urine. AntibodiesAn antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include micr...ImageRead Article Now Book Mark Article Your provider may order this test:To diagnose conditions that lead to protein in the urine If you have a lot of protein in your urine If you have signs of a blood cancer called multiple myelomaMultiple myelomaMultiple myeloma is a blood cancer that starts from a type of white blood cell in the bone marrow called plasma cells. Bone marrow is the soft, spon...ImageRead Article Now Book Mark Article Normal Results A normal result means no Bence-Jones proteins are found in your urine. What Abnormal Results Mean Bence-Jones proteins are rarely found in urine. If they are, it is usually associated with multiple myeloma.Multiple myelomaMultiple myeloma is a blood cancer that starts from a type of white blood cell in the bone marrow called plasma cells. Bone marrow is the soft, spon...ImageRead Article Now Book Mark Article An abnormal result may also be due to:An abnormal buildup of proteins in tissues and organs (amyloidosis) AmyloidosisPrimary amyloidosis is a rare disorder in which abnormal proteins build up in tissues and organs. Clumps of the abnormal proteins are called amyloid...ImageRead Article Now Book Mark Article Blood cancer called chronic lymphocytic leukemia Chronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL) is cancer of a type of white blood cells called lymphocytes. These cells are found in the bone marrow and other p...ImageRead Article Now Book Mark Article Lymph system cancer (lymphoma) Buildup in the blood of a protein called M-protein (monoclonal gammopathy of unknown significance; MGUS) Chronic renal failureChronic renal failureChronic kidney disease is the slow loss of kidney function over time. The main job of the kidneys is to remove wastes and excess water from the body...ImageRead Article Now Book Mark Article Risks There are no risks with this test.Open ReferencesReferencesGertz MA, Dispenzieri A. Amyloidosis. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 174.Rajkumar SV, Dispenzieri A. Multiple myeloma and related disorders. In: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. Abeloff's Clinical Oncology. 6th ed. Philadelphia, PA: Elsevier; 2020:chap 101. Riley RS, McPherson RA. Basic examination of urine. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 29.
